Hypophosphorous Acid Solution CAS 6303-21-5

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(1)Hypophosphorous acid(HPO2, 50%), CAS -21-5
Density:1.206g/ml,1L=1.206kg, Package:12kg/Box,

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(2)1,4-Butanediol(BDO, 14B), CAS 110-63-4, Purity>99.9%
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Bdo

CAS 110-63-4

Hypophosphorous Acid

CAS -21-5

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CAS -71-5

Red Phosphorus

CAS -14-0

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Hypophosphorous acid solution, named water, cas -21-5. n inorganic compound with chemical formula HO2P, is a colorless oily liquid, a strong reducing agent, or deliquescent crystal, easy to absorb moisture. It is decomposed into phosphoric acid and phosphine when heated to 130 &#;. Sulfuric acid oxidation at high temperature produces sulfur dioxide and sulfur. Dissolved in ether, the aqueous solution is acidic. Hypophosphorylation can reduce heavy metal salt solution to metal. When heated to 130 &#;, it is decomposed into orthophosphoric acid and phosphine, which can be used as a bactericide, a strong agent for the nervous system, a treatment agent for the metal surface, and a catalyst and hypophosphite.

 

 

 

Chemical Formula

H3O3P

Exact Mass

82

Molecular Weight

82

m/z

82 (100.0%)

Elemental Analysis

H, 3.69; O, 58.54; P, 37.78

The X-ray study confirmed that hypophosphoric acid (H2PO-2) is a tetrahedron, with two kinds of hydrogen directly connected to phosphorus. The structure is as follows: this molecule has three hydrogen atoms, but only one hydroxyl group, so it only has a monobasic acid. The hypophosphoric acid in the aqueous solution is a moderately strong acid, Ka=10-2 (25 &#;). Within the temperature range, when heated to 130 &#;, decomposition occurs mainly in the following disproportionation reactions:

1. Hypophosphorous acid solution deposition reaction:

The products include oxidation products such as diphosphine and phosphite. Hypophosphite is easily dissolved in water and ethanol. The dilute solution at normal temperature does not react with oxygen in the air, and decomposes at 100 &#; in alkaline medium:

H2PO-2+OH-&#;HPO-3+H2.

2. This product is a strong reducing agent and a weak oxidizing agent, which can reduce Cu2+, Hg2+and Ag+, such as

4Ag++H3PO2+2H2O=4Ag &#;+H3PO4+4H+.

3. The strong reducing agent itself is reduced to phosphine phosphine. Commonly used reagents in pharmaceutical industry include arsenic, zirconium, separated tantalum, niobium, etc. Barium hypophosphate is formed by the reaction of white phosphorus and hot concentrated barium hydroxide, and barium hypophosphate is precipitated by adding sulfuric acid and Ba2+.

(H2PO2)2+H2SO4=BaSO4&#;+2H3PO2.

Hypophosphite is obtained by vacuum evaporation and low-temperature crystallization.

1. Strong reducing agent, used to prepare sodium hypophosphate, calcium hypophosphate and other hypophosphates.

2. Used for electroplating bath, pharmaceutical and general reagent.

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3. It is used for the reduction of diazonium salt (removing diazo group) and the reduction to eliminate the halogen on the aromatic ring of polynitro compounds.

4. Hypophosphite is used as arsenic, zirconium, separation of tantalum, niobium and other reagents, and strong reducing agent is used in pharmaceutical industry. Hypophosphite is a very strong reducing monobasic acid, with ionization constant K=8 × 10-2. When preparing hypophosphite, commonly used supplements such as sodium salt, manganese salt, iron salt, etc.

5. Hypophosphorous acid is an important raw material for the production of high-purity hypophosphates (e.g., sodium hypophosphite, calcium hypophosphite, etc.), and these hypophosphates have a wide range of applications in the pharmaceutical field. The following is a detailed description of the specific applications of these hypophosphates in the pharmaceutical field:

 

 the application of sodium hypophosphite in the field of medicine

• As a buffer and stabilizer

Sodium hypophosphite has good buffering properties, can be used to adjust the pH value of the drug preparation, to ensure the stability of the drug in the storage and use process.
It can also interact with the active ingredients in the drug to form a stable complex, preventing the drug from degradation or deterioration in the preparation and storage process.

 

• Used in the preparation of anti-cancer drugs

Sodium hypophosphite plays an important role in the synthesis of anticancer drugs. It can be used as a reducing agent or catalyst to participate in the synthesis reaction of drugs and improve the purity and yield of drugs.
Anti-cancer drugs often contain some active groups which are sensitive to acidity and alkalinity, and the buffering effect of sodium hypophosphite can protect these groups from being damaged and ensure the effectiveness of the drugs.

 

• Other applications

Sodium Hypophosphite can also be used to prepare other types of drugs, such as antibiotics, antiviral drugs and so on.
In the field of biomedical engineering, sodium hypophosphite can also be used in the preparation of biomedical materials and artificial organs, such as bone repair materials, artificial blood vessels and so on.

 

the application of calcium hypophosphite in the field of medicine

• As calcium supplements

Calcium hypophosphite is a kind of calcium salt easily soluble in water, which can be used to prepare calcium supplements to meet the human body's demand for calcium.
Compared with other calcium salts, calcium hypophosphite has better solubility and bioavailability, which helps the absorption and utilization of calcium.

 

 

• Used in the preparation of antacids

Calcium hypophosphite can neutralize stomach acid and relieve the discomfort caused by excessive stomach acid, such as stomach pain and acid reflux.
It can also form a protective film with the gastric mucosa to prevent further stimulation and damage to the gastric mucosa by gastric acid.

 

 

• Other applications

Calcium hypophosphite can also be used in the preparation of other types of drugs, such as anti-osteoporosis drugs, anti-coagulant drugs, and so on.
In the field of biomedical engineering, calcium hypophosphite can also be used to prepare biomedical materials and artificial organs, such as bone screws, bone plates and other fixation devices.

In summary, hypophosphates (such as sodium hypophosphite, calcium hypophosphite, etc.) have a wide range of application value in the field of medicine. They can be used not only as buffers, stabilizers, calcium supplements and antacids for the preparation of pharmaceutical preparations and clinical applications, but also for the preparation of other types of drugs and biomedical materials. With the progress of science and technology and the development of the pharmaceutical field, the prospects for the application of hypophosphites in the pharmaceutical field will be even broader.

 

 

 

Hypophosphorous acid solution synthesis:

1) Reaction of yellow phosphorus with barium hydroxide

Hypophosphite is generally prepared by the reaction of yellow phosphorus and barium hydroxide, and the addition of sulfuric acid to remove barium. However, the solubility of barium salt is small, and the concentration of the prepared hypophosphite is not high, and it needs to be concentrated, recrystallized and purified.

 

3) Electrodialysis

The principle of electrodialysis is that after the electrodialysis tank is energized with direct current, the positive and negative chambers produce the following reactions:

The positive chamber and the negative chamber are separated by an anionic membrane and a cationic membrane. After direct current is applied, the positive and negative ions move to the negative and positive electrodes respectively. The anionic membrane only allows the negative ions to pass through, and the cationic membrane only allows the positive ions to pass through. At the same time, the positive electrode electrolyzes water to release oxygen and hydrogen ions, which combine with the dialyzed hypophosphite to form hypophosphoric acid, and the negative electrode releases hydrogen to release hydrogen, The electrodialysis method is simple and suitable for large-scale production. There is no waste water and residue, but the purity of the product should be further improved.

A commonly used method for preparing phosphite and hypophosphite anhydrides in the laboratory, with detailed steps as follows:

1. Prepare experimental supplies

Phosphorus block: Cut high-purity white phosphorus into small pieces and place them in a porcelain dish.

Oxygen: High purity oxygen for use.

High temperature furnace: A furnace that can withstand high temperatures and is used to heat phosphorus blocks.

Acid burette: used to measure the acidity of the product.

Salt lake reagent: used for separating hypophosphate and hypophosphate.

Water: used to cool reaction products and dissolve products.

Porcelain dish: used to hold phosphorus blocks.

Gloves, goggles, and laboratory coats: used to protect the experimenter's own safety.

2. Experimental steps

(1) Cut high-purity white phosphorus into small pieces and place them in a porcelain dish.

(2) Place the porcelain dish in a high-temperature furnace, heat it to high temperature, and maintain this temperature for a period of time to fully oxidize the phosphorus block. During this process, phosphorus reacts with oxygen to form phosphite anhydride or hypophosphite anhydride. The chemical equation for this reaction is:

4P + 3O2 &#; 2P2O3. P2O3 refers to phosphite anhydride.

(3) Inject high-purity oxygen into a high-temperature furnace and continue to react with phosphorus to generate hypophosphorous anhydride. The chemical equation for this reaction is:

4P + 5O2 &#; 2P2O5. P2O5 is hypophosphorous anhydride.

(4) Quickly remove the reaction products and cool them in water, while collecting the gases released during the cooling process. At this point, phosphite anhydride or hypophosphite anhydride will react with water to generate corresponding acids. The chemical equation for this reaction is:

P2O3+3H2O &#; 2H3PO3 (phosphite) or P2O5+3H2O &#; 2H3PO4 (hypophosphite).

(5) Place the cooled reaction product into an acid burette and titrate with a standard solution of known concentration to obtain the acidity of the product. The chemical reaction that occurs in this step is an acid-base titration reaction, where the standard solution in the burette undergoes a neutralization reaction with the generated acid. The amount of acid generated can be calculated based on the titration amount and concentration.

(6) Separate using salt lake reagents based on acidity to obtain hypophosphate and hypophosphate. The specific separation method may vary depending on the type and quality requirements of the desired product, but usually it utilizes the solubility or ion exchange properties of different substances in the solution for separation.

(7) Analyze and record the experimental results. Based on the experimental products and data, conduct chemical analysis to determine the composition, content, and quality indicators of the products, and record the experimental results.

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[Outline]

Hypophosphorous acid is also known as "hypophosphite" It is colorless oil or deliquescence crystal , it is an important fine chemical product. The main use is as reducing agent for electroless plating, phosphoric prevent discoloration of resins, it can also be used in the esterification reaction catalyst, the refrigerant, in particular for the production of high purity product sodium hypophosphite. There are several methods for preparation, the common industrial method for producing is ion exchange resin method and electrodialysis method.
The chemical properties of hypophosphorous acid, uses, toxicity, and production methods are edited by andy of Chemicalbook. (-12-04)[Chemical properties]

It is deliquescent crystals or colorless oil. Melting point: 26.5&#;. The relative density (specific gravity): 1.439 (solid, 19&#;). It is soluble in water, ethanol and ether, and it can be mixed in any proportion with water, ethanol, acetone. In the air, it easily deliquesce to syrupy liquid, and the aqueous solution is acidic.
Hypophosphorous acid is monobasic acid, in aqueous solution, Hypophosphorous acid is strong acid, Ka = 10-2 (25&#;); it is relatively stable at room temperature; disproportionation reaction can proceed at 130&#;, decompose into phosphine and phosphorous acid:
2H3PO2=H3PO4+PH3
It has strong reduction, heavy metal salt solution can be restored to metals such as Cu2 +, Hg2 +, Ag +, such as:
4Ag+H3PO2+2H2)=4Ag+H3PO4+4H+
It is weak oxidizer, it can be reduced to phosphine, phosphine when encounters strong reducing agent.[Uses]

1. Hypophosphorous acid is used as reducing agent for electroless plating;
2. It can be used to prevent discoloration of phosphoric acid resin;
3. It is used as esterification catalyst, the refrigerant;
4. It is used to produce hypophosphite, sodium salts, manganese salts, iron salts are generally used as nourishing substances;
5. Hypophosphorous acid is used in medicine and as reducing agent, the determination of arsenic, tellurium and separation of tantalum, niobium and other reagents.
6. It is strong reducing agent, It can be used for the preparation of sodium hypophosphite, calcium phosphate and other hypophosphite.
7. It can be used for the plating bath. Pharmaceuticals. reducing agent. general reagents.
8. It is strong reducing agent, it can be used in making sodium hypophosphite, calcium phosphate and other hypophosphite.
9. This product is widely used as reducing agent, Ag, Cu, Ni, Hg and other metals are reduced to the corresponding metal, for the verification of As, Nb, Ta and other reagents, it can be used for the preparation of Na, K, Ca, Mn, Fe and other types of hypophosphite.[Toxicity]

It is non-combustible. But when contacts with the hole H agent, it will cause fire. When meets oxidizing agent, violent reaction and combustion can proceed. When it is heated to high, it can decompose into highly toxic phosphine gas, or even explode. It is corrosive. Hypophosphorous acid is often added into soft drinks, and because it is not absorbed. So the risk is small, but particularly strong hypophosphite hurt gastrointestinal. Accidentally it splashes into the eyes or contacts skin, plenty of water is used to washed. Production operators should wear protective clothing and other protective clothing. Production equipment should be sealed, workshop should be ventilated well.[HAZARDS IDENTIFICATION]

Hazard statement:
Causes severe skin burns and eye damage.
Causes serious eye damage
Precautionary statements:
Do not breathe dust/fume/gas/mist/vapors/spray.
Wash thoroughly after handling.
Wear protective gloves and eye/face protection.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTRE or doctor/physician.
Store locked up.
Dispose of this material and its container to hazardous or special waste collection point.[Preparation method]

1. Phosphorus and barium hydroxide solution is heated,  barium salt Ba (H2PO2) 2 &#; 2H2O can generate, sulfuric acid is added into hypophosphorous acid barium solution, Ba2+ can precipitate:
Ba(H2PO2)2+H2SO4=BaSO4+2H3PO2
Hypophosphorous acid can be obtained by evaporating under reduced pressure and low temperature crystallization. Due to in this process, the solubility of the barium salt is small, so the concentration of obtained Hypophosphorous acid is not high, industrial product should be purified by recrystallization.
2. the barium oxide (or lime) and solution of white phosphorus is heated together to form secondary barium phosphate (or calcium), and then reacts with sulfuric acid, it is filtered, concentrated to obtain product, or sodium hypophosphite solution proceeds H-type ion exchange resin can derive product. This method requires a large amount of resin, and resin regeneration and washing step is cumbersome, it generally costs more than $ 7 per pound, it is only suitable for small batch production, and not suitable for large-scale industrial applications.
3. Hypophosphorous acid is prepared by electrodialysis method, wherein the electrodialysis cell divides into three parts, they are anode chamber, raw material chamber and cathode chamber, the intermediate is separated by anionic membrane and cationic membrane, between two membranes sodium hypophosphite solution is placed (concentration of 100g/L~500g/L), anode chamber is dilute solution of Hypophosphorous acid 5g/L, anode chamber is dilute sodium hydroxide solution ( 5g /L), between the poles DC (3V~36V) is passed, anode releases oxygen, and generates secondary product of Hypophosphorous acid; cathode emits hydrogen, and generates secondary product of sodium hydroxide, the reaction time is 3~21h. The reactions of anode chamber and cathode chamber are as follows:
anode chamber:
H2O==H++OH-
2OH-==O2+2H2O+4e
H++H2PO2-==H3PO2
cathode chamber:
H2O==H++OH-
2H++2e==H2
Na++OH-==NaOH
Electrodialysis method of preparation Hypophosphorous acid is simple and equipment investment is small, it is suitable for mass production.
4. Starting from the industrial grade sodium hypophosphite, Cl-, SO42-anions which affect the quality indicators of Hypophosphorous acid are removed by precipitation, heavy metal ions are removed from the solution by forming sulfide, and then using strong acid cation exchange resin to obtain sodium secondary phosphate, high purity grade product can obtain. The process can produce high-grade secondary phosphate, technically is feasible, the process is simple, easy operation, good product quality, it can meet the needs of the electronics industry, defense industry and other high-tech fields.

figure 1 Production Process of Hypophosphorous Acid from Industrial Sodium Hypophosphite.
5. Ion exchange resin method: about 70g of cation exchange resin wetted with water is packed into a glass tube with 5 mol/L hydrochloric acid circulating about 15min, after thoroughly washed with water, high purity aqueous sodium hypophosphite aqueous solution (15 g/60 ml H2O) flows through it, the resin column is first washed with 50 ml, then with 25 rnl distilled water. The effluent acid and washing is combined, it is concentrated by evaporation in water bath. The concentrated acid is placed in high vacuum with P205 dryer for dehydration, cooling and crystallization, filtration, recrystallization, to obtain hypophosphorous acid product.[Production method]

Ion exchange resin method: put about 70 g water-soluble cation exchange resins to fill into a glass tube. Circulate with 5 mol/L hydrochloric acid for about 15 min and wash sufficiently with water. Have a high aqueous sodium hypophosphite solution (15 g/60 ml H2O) to flow through the resin column, followed by being washed first with 50 ml water, and then rinsing with 25 rnl distilled water. The effluent acid and the washings were combined and concentrated by evaporation on a water bath. The concentrated acid is send to the highly vacuum, P205 dryer for dehydration, followed by cooling crystallization, filtration and recrystallization to obtain the finished product of hypophosphorous acid.